CelluRex®
cellulite treatment
|
|
|
|
Clinical Trials |
|
60 days controlled Clinical Trials The efficacy study of the active ingredients in CelluRex with Liporeductyl® was conducted in a group of twenty five female subjects with cellulite imperfections, aged between 18 and 60. The methods used were video capillaroscopy images and cell culture model of human pre-adipocytes (fat cells). Frontal photographs were taken at intervals of one week and at the end of the study in order to obtain mean parameters, thus taking into account slight day-to-day variability. Protocol: The subjects applied a cream with the active ingredients in CelluRex on the affected cellulite areas - buttocks and thighs. Applications were conducted twice daily for 60 days. Each subject acted as his/her own control. The twenty subjects had an average age of 55 years. Reduction of size of buttocks 35% of patients showed a very significant decrease of 3 to 4 CM while 40% showed a significant decrease of 1 to 2 CM.
Reduction of size of thighs 85% of patients presented a significant decrease of 1 to 2 CM in the size of their thigh circumference.
Reduction of body fat mass - cellulite 50% of patients showed a significant decrease of 2 to 3 kg.
Cellulite prevention - Inhibition of adipocyte (cellulite fat) maturation An in vitro cell culture model of human pre-adipocytes was used, and they were stimulated to differentiate to adipocytes. This was accomplished by using a potent mixture of differentiation agents which induces a strong accumulation of fat inside the lipid droplets contained in the pre-adipocytes. The lipid droplets were visualized by phase contrast microscopy and quantified by image analysis. Results indicate that CelluRex with Liporeductyl® is a strong inhibitor of cellulite fat maturation. The microscopy photographs in the figure below show the dramatic decrease in cellulite fat cell formation.
Activation of microcirculation An in vivo test involving 20 female patients of all age groups proved the properties of CelluRex with Liporeductyl as an activator of microcirculation. Video capillaroscopy images show an improvement in the structure of micro capillaries and a decrease in micro hemorrhages. This appears as a rosier complexion, less evident presence of nodules and an improvement in the degree of orange skin.
|
